The world of weight management has been going through a dramatic evolution in recent years with the rise of GLP-1 medications. According to a recent KFF Health Tracking Poll, approximately one in eight U.S. adults uses a GLP-1 medication such as semaglutide (marketed as Ozempic and Wegovy) and tirzepatide (sold as Mounjaro and Zepbound). A quarter of those using the medications cited weight loss as their primary goal according to that same study.

A recent report by Dandelion Health, based on electronic health records of nearly 17,000 patients who had been prescribed GLP-1 medications, found that people using the medicines had lost an average of around 1.4% of their starting body weight after three months, which increased to an average of around 3% total weight loss after 12 months of treatment.

Even though GLP-1 medications are highly effective, many people stop taking them too soon, missing out on long-term benefits. According to a Blue Health Intelligence report, 30% of patients stopped treatment within four weeks, before reaching their targeted dose and many people discontinued use of GLP-1 medications before achieving clinically meaningful weight loss.

So, whilst there are few doubts about the effectiveness of GLP-1 drugs, those who begin using the medications clearly face a number of challenges when it comes to staying the course of their treatment. 

Challenges along the GLP-1 Journey

So GLP-1 medications have revolutionized weight management, but success requires more than just taking your prescribed dose. Many users stop treatment early due to various challenges:

• Unrealistic expectations about the timeline for results
• Difficulty managing side effects
• Insurance coverage and cost concerns
• Struggles with maintaining necessary lifestyle changes

Unrealistic Timeline Expectations

It’s really important to understand that weight loss with GLP-1 medications isn't an overnight transformation. While some people see initial results within weeks, sustainable weight loss is typically a longer term process. Setting realistic expectations from the start helps prevent disappointment and early discontinuation. Remember that sustainable weight loss of 1-2 pounds per week is considered healthy and more likely to stay off long-term.

Difficulty managing side effects

Side effects represent one of the most significant challenges for GLP-1 users. Common experiences include:

• Nausea
• Digestive issues
• Fatigue 
• Changes in appetite
• Headaches and other physical discomforts

Whilst these side effects are a common reason for stopping treatment, many can be managed effectively with the right approach. More on this later.

Insurance coverage and cost concerns

Cost remains a significant barrier for many GLP-1 users. Without insurance coverage, these medications are very expensive. Even with insurance, challenges such as high copays, complex coverage requirements and prior authorizations can prove challenging. The financial aspect of GLP-1 medications can be challenging, but several strategies can help manage costs.

Necessary Lifestyle Changes

While GLP-1 medications help control appetite, they don't automatically create healthy habits. Any weight loss journey requires lifestyle changes and the adoption of healthy habits, particularly around diet and exercise.

Healthy Habits for GLP-1 Success

For those embarking on a weight loss journey with Wegovy or another GLP-1 medication, there are a number of things that you can do to improve your chances of lasting the course and achieving positive results.

1. Ensure you have proper medical support

Regular medical support plays a crucial role in your success. Findings from the Blue Cross Blue Shield data emphasize the important role that providers can play in helping patients stick with their treatment with GLP-1s. According to Dr. Razia Hashmi, vice president of clinical affairs for the Blue Cross Blue Shield Association, each additional follow-up visit increases your chances of staying on treatment by 60%. Your healthcare team isn't just there for prescriptions—they're your partners in:

• Monitoring your progress
• Managing side effects
• Adjusting treatment plans as needed
• Ensuring safe and effective long-term use

2. Eat a balanced diet that aligns with your goals and medication

"Pairing GLP-1 medications with a balanced, nutrient-dense diet is key to sustainable weight management," explains Danielle McAvoy, Registered Dietitian. Recent research published in Obesity emphasizes specific nutritional guidelines for GLP-1 users to prevent deficiencies and optimize weight loss outcomes.

Best Foods to Compliment GLP-1 Medications:

• Protein-Rich Options: Focus on lean meats, fish, eggs, Greek yogurt, and plant-based proteins like tofu and beans. These foods help preserve muscle mass and support healthy metabolism.
• Fiber-Forward Choices: Incorporate whole grains, leafy greens, berries, and legumes to support digestive health and prevent constipation.
• Healthy Fats: Include avocados, olive oil, and fatty fish to support nutrient absorption and reduce gallstone risk.
• Micronutrient-Dense Foods: Choose fortified dairy or plant-based milk alternatives and dark leafy greens to prevent vitamin deficiencies.

Foods to Minimize on GLP-1 Medications:

• Fried and heavily processed foods that can worsen nausea
• Sugary treats and refined carbohydrates that cause blood sugar spikes
• Carbonated beverages that may increase bloating
• Alcohol and excessive caffeine, which can contribute to dehydration

3. Drink plenty of water (& other fluids)

Research shows that GLP-1 medications can suppress thirst alongside appetite, making intentional hydration crucial. While about 20% of daily fluid intake comes from food, it's essential to maintain regular water consumption throughout the day. Consider:

• Setting regular water intake reminders
• Keeping a water bottle nearby
• Including hydrating beverages like herbal tea and broth-based soups
• Monitoring urine color as a hydration indicator

4. Be physically active

Studies confirm that combining GLP-1 medications with regular physical activity, particularly strength training, can be a highly effective strategy for sustainable weight loss, as it:

• Enhances the medication’s appetite suppressing effects
• Boosts metabolism
• Supports muscle preservation
• Improves insulin sensitivity
• Enhances overall well-being

Always consult your healthcare team before making significant changes to your exercise routine, especially when starting GLP-1 medication.

5. Practice Mindful Meal Planning

Chances of success with GLP-1 medications can be boosted through thoughtful preparation and mindful eating strategies. Research published in the International Journal of Behavioral Nutrition and Physical Activity indicates that meal planning is associated with better dietary quality and lower odds of being overweight or obese. Strategic meal planning while using GLP-1 medications helps you:

• Ensure adequate nutrition despite reduced appetite
• Maintain consistent eating schedules
• Make healthier food choices
• Manage portion sizes effectively

Setting Yourself Up for GLP-1 Weight Loss Success

While GLP-1 medications provide powerful support for weight management, combining them with healthy habits creates a comprehensive approach for sustainable results. Territory Foods offers perfectly portioned, nutrient-dense meals that align with GLP-1 nutritional guidelines, making it easier to maintain healthy eating habits while on your weight loss journey.

Struggling to get the right nutrition on your GLP-1 journey? Our GLP-1 Companion Meals make it easy to stay on track—chef-prepared, nutrient-dense, and designed to support your success. Try your first meal today! 

Remember: Always consult with your healthcare provider before making any significant changes to your diet or exercise routine while taking GLP-1 medications.